 ChiranjeeviShankar Prasad / Shankar Dada | Shankar Prasad / Shankar Dada |
 SrikanthATM | ATM |
 Sonali BendreDr. Sunitha "Chitti" | Dr. Sunitha "Chitti" |
 Paresh RawalDr. J. Rama Lingeshwara Rao | Dr. J. Rama Lingeshwara Rao |
 Girish KarnadSatya Prasad | Satya Prasad |
 Vennira Aadai NirmalaShankar Prasad's mother | Shankar Prasad's mother |
 M. S. NarayanaDr. Chidambaram MBBS, FRCS | Dr. Chidambaram MBBS, FRCS |
 Surya Bhagawan DasDr. Mohammed Rafi | Dr. Mohammed Rafi |
 Deepti NallamothuMeena | Meena |
 SharwanandVijay | Vijay |
 Panja Vaisshnav TejCameo Appearance as Child Artist | Cameo Appearance as Child Artist |
 AliThief | Thief |
 Ahuti PrasadCorrupted Doctor | Corrupted Doctor |
 Gauahar KhanSpecial appearance in song | Special appearance in song |
 Venu MadhavMalhotra, Shankar's henchmen | Malhotra, Shankar's henchmen |
| TTirupati PrakashNot listed | Not listed |
 Chalapathi RaoNot listed | Not listed |
| BBhupinder SinghPandu Dada | Pandu Dada |
 BanerjeeCorrupted Faculty | Corrupted Faculty |
 Narsing YadavShankar's henchmen | Shankar's henchmen |
 Thotapalli MadhuNot listed | Not listed |
| AAthili LakshmiNot listed | Not listed |
 Duvvasi MohanNot listed | Not listed |
 Karate Kalyani PadalaNot listed | Not listed |
 Anjala ZaveriCameo Appearance in “Chaila Chaila” song | Cameo Appearance in “Chaila Chaila” song |
| Gauahar KhanSpecial appearance in the song "Naa Pera Kanchan Mala" | Special appearance in the song "Naa Pera Kanchan Mala" |
 Pawan KalyanSpecial appearance in song | Special appearance in song |
