Glendon Wasey is a fortune hunter looking for a fast track out of China. Gloria Tatlock is a missionary nurse seeking the curing powers of opium for her patients. Fate sets them on a hectic, exotic, and even romantic quest for stolen drugs. But they are up against every thug and smuggler in Shangai.
| Actor | Role |
|---|---|
 Sean PennGlendon Wasey | Glendon Wasey |
 MadonnaGloria Tatlock | Gloria Tatlock |
 Paul FreemanWalter Faraday | Walter Faraday |
 Richard GriffithsWillie Tuttle | Willie Tuttle |
 Clyde KusatsuJoe Go | Joe Go |
 Philip SayerJustin Kronk | Justin Kronk |
 Lim Kay TongMei Gan | Mei Gan |
 Victor WongHo Chong | Ho Chong |
 Professor Toru TanakaYamagani San | Yamagani San |
 Michael AldridgeMr. Burns | Mr. Burns |
 Sarah LamChina Doll's Maid | China Doll's Maid |
 George HarrisonNightclub Singer | Nightclub Singer |
| SSonserai LeeChina Doll | China Doll |
| GGeorge SheWu Ch'En She | Wu Ch'En She |
| WWon Gam BorRickshaw King | Rickshaw King |
| TTo Chee KanChina Doll's Boatman | China Doll's Boatman |
 Philip TanShip's Officer | Ship's Officer |
| TTo Wai-WoNot listed | Not listed |