Father-to-be Alan is shocked to learn that he was born a sextuplet. With his newfound brother Russell riding shotgun, the duo sets out on a hilarious journey to reunite with their remaining long-lost siblings.
| Actor | Role |
|---|---|
 Marlon WayansAlan / Russell / Dawn / Jasper / Ethan / Baby Pete / Lynette | Alan / Russell / Dawn / Jasper / Ethan / Baby Pete / Lynette |
 Bresha WebbMarie | Marie |
 Michael Ian BlackDoug | Doug |
 Molly ShannonLinda | Linda |
 Glynn TurmanLeland | Leland |
 Debbi MorganJanet | Janet |
 Robert PralgoDr. Williams | Dr. Williams |
 Jwaundace CandecePrison Guard | Prison Guard |
| JJason GrahamDr. Ellis | Dr. Ellis |
 Casey HendershotTrucker | Trucker |
 Grace JunotDr. Greenberg | Dr. Greenberg |
| Robert PralgoDr. Theodore Williams | Dr. Theodore Williams |
 Scott HunterTrucker #2 | Trucker #2 |