 Simon BakerRoderick Blank | Roderick Blank |
 Winona RyderDeath Nell / Gillian De Raisx (#101) | Death Nell / Gillian De Raisx (#101) |
 Leslie BibbDr. Miranda Storm | Dr. Miranda Storm |
 Mindy CohnTrixie | Trixie |
 Julie BowenFiona Wormwood (#29) | Fiona Wormwood (#29) |
 Dash MihokLester | Lester |
 Neil FlynnZack | Zack |
 Patton OswaltFred | Fred |
 Frances FisherHope Hartlight (#80) | Hope Hartlight (#80) |
 Robert WisdomAlpha | Alpha |
 Marshall BellVictor Rose III | Victor Rose III |
 Sophie MonkCynthia Rose (#31) | Cynthia Rose (#31) |
 Tanc SadeBeta | Beta |
 Natassia MaltheBambi (#63) | Bambi (#63) |
 Pollyanna McIntoshThumper (#64) | Thumper (#64) |
 Rob BenedictBow-Tie Bob | Bow-Tie Bob |
 Jessica KiperPrecious / Carlotta Valdes (#30) | Precious / Carlotta Valdes (#30) |
 Winter Ave ZoliAlexis De Large (#37) | Alexis De Large (#37) |
 Cindy PickettRoderick's Mother | Roderick's Mother |
 Candice CokeGreta Samsa (#32) | Greta Samsa (#32) |
 Christopher StapletonTerry Fenchel (#71) | Terry Fenchel (#71) |
 RettaEthel Walters (#100) | Ethel Walters (#100) |
 Corinne ReillyLizzie | Lizzie |
 Amanda WalshStewardess Kathleen | Stewardess Kathleen |
 Indira VarmaDevon Sever | Devon Sever |
 Bryan OkesBuzzkilling Bodyguard | Buzzkilling Bodyguard |
 Zachary GordonBarbecue Brat | Barbecue Brat |
| SSkyler James SandakRoderick Blank Jr. | Roderick Blank Jr. |
 Nicole BilderbackDr. Mirabella Stone (#66) | Dr. Mirabella Stone (#66) |
 Keram Malicki-SánchezMaster Bitchslap | Master Bitchslap |
