Seth Rogen and friends combine stand-up, sketches and music for an outrageous comedy special that could only come from the mind of Seth. Guests include Tiffany Haddish, Sarah Silverman, Michelle Wolf, John Mulaney, Michael Che, David Chang, Ike Barinholtz, Chelsea Peretti, Kumail Nanjiani, Jon Lovitz, Jeff Goldblum, Sacha Baron Cohen, Nick Kroll, Post Malone, Chris Hardwick, and Craig Robinson & The Nasty Delicious.
| Actor | Role |
|---|---|
 Seth RogenSelf | Self |
 Ike BarinholtzSelf | Self |
 Michael CheSelf | Self |
 Sacha Baron CohenSelf | Self |
 Jeff GoldblumSelf | Self |
 Tiffany HaddishSelf | Self |
 Chris HardwickSelf | Self |
 Nick KrollSelf | Self |
 John MulaneySelf | Self |
 Kumail NanjianiSelf | Self |
 Chelsea PerettiSelf | Self |
 Craig RobinsonSelf | Self |
 Post MaloneSelf | Self |
 Sarah SilvermanSelf | Self |
 Lauren Miller RogenSelf | Self |
 Justin RoilandChar (voice) | Char (voice) |
 Michelle WolfSelf | Self |
 Zach HadelIty (voice) | Ity (voice) |
 Matt VogelKermit the Frog/Floyd Pepper/Camilla the Chicken (voice) | Kermit the Frog/Floyd Pepper/Camilla the Chicken (voice) |
 Eric JacobsonFozzie Bear/Sam Eagle/Animal (voice) | Fozzie Bear/Sam Eagle/Animal (voice) |
 Dave GoelzGonzo/Waldorf (voice) | Gonzo/Waldorf (voice) |
 Peter LinzWalter/Statler (voice) | Walter/Statler (voice) |
 Snoop DoggSelf (archive footage) | Self (archive footage) |
 Kevin HartSelf (archive footage) | Self (archive footage) |
 Hannibal BuressSelf (archive footage) | Self (archive footage) |