In the main events of Ice Age: Collision Course, Scrat is captured by Scratazons who take away his acorn. Now, Scrat must rescue his Acorn and escape before the aliens can catch him.
| Actor | Role |
|---|---|
 Neil deGrasse TysonNarrator | Narrator |
 Chris WedgeScrat (voice) | Scrat (voice) |
 Karen DisherScratazons (voice) | Scratazons (voice) |
 John LeguizamoSid (voice) (uncredited) | Sid (voice) (uncredited) |
 Jennifer LopezShira (voice) (uncredited) | Shira (voice) (uncredited) |
 Simon PeggBuck (voice) (uncredited) | Buck (voice) (uncredited) |
 Ray RomanoManny (voice) (uncredited) | Manny (voice) (uncredited) |
 Adam DevineJulian (voice) (uncredited) | Julian (voice) (uncredited) |