Mecha Mutt, a revolutionary remote-controlled lunar rover resembling a large canine, goes rogue at Houston's Annual Science Expo. Scooby-Doo! Mecha Mutt Menace is the fourth in a series of direct-to-video short films.
| Actor | Role |
|---|---|
 Frank WelkerScooby-Doo / Fred Jones (voice) | Scooby-Doo / Fred Jones (voice) |
 Matthew LillardShaggy Rogers (voice) | Shaggy Rogers (voice) |
 Grey DeLisleDaphne Blake (voice) | Daphne Blake (voice) |
 Mindy CohnVelma Dinkley (voice) | Velma Dinkley (voice) |
 Julie BowenDr. Devon Albright (voice) | Dr. Devon Albright (voice) |
 Lacey ChabertMelanie Staples (voice) | Melanie Staples (voice) |
 Alan RachinsDr. Ned Staples (voice) | Dr. Ned Staples (voice) |
 Paul ReubensIrv (voice) | Irv (voice) |
 Phil LaMarrStan (voice) | Stan (voice) |