When Scooby and the gang get trapped in a video game created for the gang, they must fight against the 'Phantom Virus.' To escape the game they must go level by level and defeat the game once and for all.
| Actor | Role |
|---|---|
 Scott InnesScooby-Doo / Shaggy (voice) | Scooby-Doo / Shaggy (voice) |
 Grey DeLisleDaphne (voice) | Daphne (voice) |
 B.J. WardVelma (voice) | Velma (voice) |
 Frank WelkerFred (voice) | Fred (voice) |
 Gary Anthony SturgisPhantom Virus (voice) | Phantom Virus (voice) |
 Joe AlaskeyWembley (voice) | Wembley (voice) |
 Bob BergenEric (voice) | Eric (voice) |
 Tom KaneProfessor Kaufman (voice) | Professor Kaufman (voice) |
 Mikey KelleyBill (voice) | Bill (voice) |