Get ready to Rock! Scooby-Doo and the Mystery Inc. Gang team up with the one and only KISS in this all-new, out-of-this-world adventure! We join the Gang at KISS World – the all-things-KISS theme park, as they investigate a series of strange hauntings. With help from KISS, they discover that the Crimson Witch has returned to summon The Destroyer from the alternate dimension of Kissteria! The evil duos ghastly plan, to destroy the earth! Can the Gang's cunning and KISS's power of rock save the day?!
| Actor | Role |
|---|---|
 Frank WelkerFred / Scooby-Doo (voice) | Fred / Scooby-Doo (voice) |
 Mindy CohnVelma (voice) | Velma (voice) |
 Matthew LillardShaggy (voice) | Shaggy (voice) |
 Grey DeLisleDaphne (voice) | Daphne (voice) |
 Gene SimmonsDemon (voice) | Demon (voice) |
 Paul StanleyStarchild (voice) | Starchild (voice) |
 Eric SingerCatman (voice) | Catman (voice) |
 Garry MarshallManny Goldman (voice) | Manny Goldman (voice) |
 Doc McGheeChip McGhoo (voice) | Chip McGhoo (voice) |
 Pauley PerretteDelilah Domino (voice) | Delilah Domino (voice) |
 Rachel RamrasShandi Strutter (voice) | Shandi Strutter (voice) |
 Penny MarshallThe Elder (voice) | The Elder (voice) |
 Darius RuckerThe Destroyer (voice) | The Destroyer (voice) |
 Jennifer CarpenterChikara (voice) | Chikara (voice) |
 Jason MewesWorker #1 (voice) | Worker #1 (voice) |
 Kevin SmithWorker #2 (voice) | Worker #2 (voice) |
 Tony CervoneAnnouncer (voice) | Announcer (voice) |
 Tommy ThayerSpaceman (voice) | Spaceman (voice) |