Cindy finds out the house she lives in is haunted by a little boy and goes on a quest to find out who killed him and why. Also, Alien "Tr-iPods" are invading the world and she has to uncover the secret in order to stop them.
| Actor | Role |
|---|---|
 Anna FarisCindy | Cindy |
 Regina HallBrenda | Brenda |
 Craig BierkoTom | Tom |
 Bill PullmanHenry Hale | Henry Hale |
 Anthony AndersonMahalik | Mahalik |
 Leslie NielsenPresident Baxter Harris | President Baxter Harris |
 Molly ShannonMarilyn | Marilyn |
 Michael MadsenOliver | Oliver |
 Chris ElliottEzekiel | Ezekiel |
 Carmen ElectraHolly | Holly |
 Shaquille O'NealShaq | Shaq |
 Phil McGrawDr. Phil | Dr. Phil |
 Cloris LeachmanMrs. Norris | Mrs. Norris |
 Conchita CampbellRachel | Rachel |
 Beau MirchoffRobbie Ryan | Robbie Ryan |
 Kevin HartCJ | CJ |
 DeRay DavisMarvin | Marvin |
 Simon RexGeorge | George |
| YYoungBloodZYoungBloodZ | YoungBloodZ |
 Bryan CallenHarper | Harper |
 Alonzo BoddenJamison | Jamison |
 Dave AttellKnifeman | Knifeman |
 Holly MadisonBlonde #1 | Blonde #1 |
 Bridget MarquardtBlonde #2 | Blonde #2 |
 Kendra WilkinsonBlonde #3 | Blonde #3 |
 Drew MikuskaCody | Cody |
 ChingyChingy | Chingy |
 FabolousGunman | Gunman |
 Lil JonGloating Driver | Gloating Driver |
 Henry MahMr. Koji | Mr. Koji |