 Paul MuniAntonio 'Tony' Camonte | Antonio 'Tony' Camonte |
 Ann DvorakFrancesca 'Cesca' Camonte | Francesca 'Cesca' Camonte |
 Karen MorleyPoppy | Poppy |
 Osgood PerkinsJohn 'Johnny' Lovo | John 'Johnny' Lovo |
 C. Henry GordonInsp. Ben Guarino | Insp. Ben Guarino |
 George RaftGuino Rinaldo | Guino Rinaldo |
 Vince BarnettAngelo | Angelo |
 Boris KarloffGaffney | Gaffney |
 Purnell PrattMr. Garston, publisher | Mr. Garston, publisher |
 Tully MarshallManaging Editor | Managing Editor |
 Inez PalangeMrs. Camonte | Mrs. Camonte |
 Edwin MaxwellChief of Detectives | Chief of Detectives |
 Jean HarlowBlonde at Paradise Club | Blonde at Paradise Club |
 Henry ArmettaPietro, the Barber (uncredited) | Pietro, the Barber (uncredited) |
| GGus ArnheimOrchestra Leader (uncredited) | Orchestra Leader (uncredited) |
 Eugenie BessererCitizens Committee Member (uncredited) | Citizens Committee Member (uncredited) |
 Maurice BlackJim, the Headwaiter (uncredited) | Jim, the Headwaiter (uncredited) |
| JJames ConatyNightclub Patron (uncredited) | Nightclub Patron (uncredited) |
 Gino CorradoWaiter at Columbia Cafe (uncredited) | Waiter at Columbia Cafe (uncredited) |
 Virginia DabneyMabel (uncredited) | Mabel (uncredited) |
 William B. DavidsonCitizens Committee Member (uncredited) | Citizens Committee Member (uncredited) |
 James DurkinNewspaper Man (uncredited) | Newspaper Man (uncredited) |
 Bill ElliottMan Outside Theatre (uncredited) | Man Outside Theatre (uncredited) |
 Eddie FetherstonReporter (uncredited) | Reporter (uncredited) |
 Paul FixHood with Gaffney (uncredited) | Hood with Gaffney (uncredited) |
| DDick GordonNightclub Patron (uncredited) | Nightclub Patron (uncredited) |
 Howard HawksMan on Bed (uncredited) | Man on Bed (uncredited) |
 Brandon HurstCitizens Committee Member (uncredited) | Citizens Committee Member (uncredited) |
 Sydney JarvisBartender (uncredited) | Bartender (uncredited) |
 John KellyOne of Costillo's Hoods (uncredited) | One of Costillo's Hoods (uncredited) |
