 Seth RogenFrank / Sergeant Pepper / Peanut Butter (voice) | Frank / Sergeant Pepper / Peanut Butter (voice) |
 Kristen WiigBrenda (voice) | Brenda (voice) |
 Jonah HillCarl (voice) | Carl (voice) |
 Bill HaderFirewater / Tequila / El Guaco (voice) | Firewater / Tequila / El Guaco (voice) |
 Michael CeraBarry (voice) | Barry (voice) |
 James FrancoDruggie (voice) | Druggie (voice) |
 Danny McBrideHoney Mustard (voice) | Honey Mustard (voice) |
 Craig RobinsonGrits (voice) | Grits (voice) |
 Paul RuddDarren (voice) | Darren (voice) |
 Nick KrollDouche (voice) | Douche (voice) |
 David KrumholtzKareem Abdul Lavash (voice) | Kareem Abdul Lavash (voice) |
 Edward NortonSammy Bagel Jr. (voice) | Sammy Bagel Jr. (voice) |
 Salma Hayek PinaultTeresa Taco (voice) | Teresa Taco (voice) |
 Anders HolmTroy (voice) | Troy (voice) |
 Scott UnderwoodGum / Twink / Krinkler's Chips / Pizza / Peanut (voice) | Gum / Twink / Krinkler's Chips / Pizza / Peanut (voice) |
 Sugar Lyn BeardBaby Carrot / Cookies (voice) | Baby Carrot / Cookies (voice) |
 Conrad VernonToilet Paper / Sauerkraut / Catcall Sausage / Grape #1 / Beer Can / Pop Bottle (voice) | Toilet Paper / Sauerkraut / Catcall Sausage / Grape #1 / Beer Can / Pop Bottle (voice) |
 Ian James CorlettApple / Tickilish Licorice / Relish / Bag of Dog Food (voice) | Apple / Tickilish Licorice / Relish / Bag of Dog Food (voice) |
 Michael DaingerfieldChunk Munchers Cereal / Light Bulb / Indian Chutney (voice) | Chunk Munchers Cereal / Light Bulb / Indian Chutney (voice) |
 Jason SimpsonPlum #2 / Beer Keg / Fat Guy / Fit Man (voice) | Plum #2 / Beer Keg / Fat Guy / Fit Man (voice) |
 Vincent TongPislitz Chips / Juice Box / Jamaican Rum (voice) | Pislitz Chips / Juice Box / Jamaican Rum (voice) |
| KKaren E. WrightDiner Waitress | Diner Waitress |
| LLauren Miller RogenCamille Toh / Tampon (voice) | Camille Toh / Tampon (voice) |
 Sam VincentOld Pork Sausage / Refried Beans / Sandwich / Pop Tart / Licorice Rope (voice) | Old Pork Sausage / Refried Beans / Sandwich / Pop Tart / Licorice Rope (voice) |
 Greg TiernanPotato / Noodle Soup / Larry the Corn (voice) | Potato / Noodle Soup / Larry the Corn (voice) |
 Brian DobsonItalian Tomato / Lettuce (voice) | Italian Tomato / Lettuce (voice) |
 Harland WilliamsKetchup / Drug Dealer / Baba Ganoush (voice) | Ketchup / Drug Dealer / Baba Ganoush (voice) |
 Alistair AbellMariachi Salsa / Gefilte Fish (voice) | Mariachi Salsa / Gefilte Fish (voice) |
 Iris ApatowBerry Good Candies / Grape #3 / Coconut Milk (voice) | Berry Good Candies / Grape #3 / Coconut Milk (voice) |
 Michael DobsonQueso (voice) | Queso (voice) |
