An Irish-American girl asks the saint to guide her family and save them from an alderman.
| Actor | Role |
|---|---|
 Ann BlythSally O'Moyne | Sally O'Moyne |
 Edmund GwennGrandpa Pat Ryan | Grandpa Pat Ryan |
 John McIntireAlderman Percival Xavier 'Goldtooth' McCarthy | Alderman Percival Xavier 'Goldtooth' McCarthy |
 Gregg PalmerJohnny Evans (as Palmer Lee) | Johnny Evans (as Palmer Lee) |
 Hugh O'BrianDanny O'Moyne | Danny O'Moyne |
 Jack KellyMike O'Moyne | Mike O'Moyne |
 Frances BavierMrs. Kitty 'Mom' O'Moyne | Mrs. Kitty 'Mom' O'Moyne |
 Otto HulettPop O'Moyne | Pop O'Moyne |
 Kathleen HughesLois Foran | Lois Foran |
 George MathewsFather Kennedy | Father Kennedy |
 Lamont JohnsonWillie O'Moyne | Willie O'Moyne |
 King DonovanHymie Callahan, Trainer | Hymie Callahan, Trainer |
 Bess FlowersCountry Club Patron | Country Club Patron |
 Alix TaltonJeanne | Jeanne |
 Frank GiffordMcCarthy's Son | McCarthy's Son |
| JJoe GrayCrunch | Crunch |
 Dabbs GreerMr. Parker | Mr. Parker |
| JJune HedinHelen | Helen |
| MMary Alan HokansonSister Leonard | Sister Leonard |
 Eilene JanssenYoung Jeanne | Young Jeanne |
 Joseph MellMr. Shapiro | Mr. Shapiro |
 Robert NicholsHenry | Henry |
 George D. WallaceJimmy Mulvaney | Jimmy Mulvaney |