James Franco's Sal chronicles the final hours of the life of actor Sal Mineo, one-time teen idol and star of the blockbuster films Rebel Without a Cause and Exodus.
| Actor | Role |
|---|---|
 Val LaurenSal Mineo | Sal Mineo |
 Jim ParrackKeir Dullea | Keir Dullea |
 James FrancoMilton Katselas | Milton Katselas |
| VVince JolivetteBilly Belasco | Billy Belasco |
| TTrevor NeuhoffMichael Mason | Michael Mason |
| SStacey MillerNancy Barr | Nancy Barr |
 Brian GoodmanDet. Tankersley | Det. Tankersley |
| RRaymond T. WilliamsLionel Ray Williams | Lionel Ray Williams |
| BBoyd SmithBoyd | Boyd |
| JJacquelyn DemeNurse | Nurse |
 Jason FoxSteven Gustafson | Steven Gustafson |
 Brian LallyDetective Pia | Detective Pia |
| CChristian OlaveRay Evans | Ray Evans |
 Jocelyn AyannaMabel | Mabel |
| FFelicity BryantMonica Merrem | Monica Merrem |
| TTony CalleClub Patron | Club Patron |
 Joseph Michael HarrisPalm Restaurant Patron | Palm Restaurant Patron |
| SStephen McCainSpa Patron | Spa Patron |
 Inbal AmiravAnnabelle | Annabelle |