What if Jesus and Buddha were living on Earth in modern times? What if they shared an apartment in Japan? Saint☆Oniisan is a humorous drama about daily lives of Jesus Christ and Gautama Buddha who are living together as roommates in a Tokyo apartment while taking a vacation on Earth. The comedy often involves jokes about Christianity, Buddhism, and all things related, as well as the main characters' attempts to hide their identities and understand modern society in Japan.
| Actor | Role |
|---|---|
 Kenichi MatsuyamaJesus Christ | Jesus Christ |
 Shota SometaniGautama Buddha | Gautama Buddha |
 Jiro SatoDoctor | Doctor |
 Umi YamanoLandlady | Landlady |