After the bloody battle against Hades, the goddess Athena and her saints are still recovering when they find themselves face to face with their newest and most formidable foe: the dreadful moon goddess Artemis. Artemis replaces Athena as the earth guardian deity and takes over the Sanctuary, turning Athena's Saints into her servants. Upon invading the Sanctuary, the Bronze Saints learn that Athena was banished by Artemis and decide to fight the moon goddess in order to rescue their true goddess and free the Earth from Artemis's ominous control.
| Actor | Role |
|---|---|
 Toru FuruyaSeiya (voice) | Seiya (voice) |
 Hirotaka SuzuokiShiryu (voice) | Shiryu (voice) |
 Koichi HashimotoHyoga (voice) | Hyoga (voice) |
 Ryo HorikawaShun (voice) | Shun (voice) |
 Hideyuki HoriIkki (voice) | Ikki (voice) |
 Keiko HanSaori Kido / Athena (voice) | Saori Kido / Athena (voice) |
 Hikaru MidorikawaIcarus / Toma (voice) | Icarus / Toma (voice) |
 Fumiko InoueYoung Toma (voice) | Young Toma (voice) |
 Yuriko YamamotoAquila Marin (voice) | Aquila Marin (voice) |
 Mami KoyamaOphiuchus Shaina (voice) | Ophiuchus Shaina (voice) |
 Masaya OnosakaHydra Ichi (voice) | Hydra Ichi (voice) |
 Hideo IshikawaUnicorn Jabu (voice) | Unicorn Jabu (voice) |
 Nobuo TobitaAries Shion (voice) | Aries Shion (voice) |
 Kenyu HoriuchiLibra Dohko (voice) | Libra Dohko (voice) |
 Yurika HinoArtemis (voice) | Artemis (voice) |
 Toshiyuki MorikawaTheseus (voice) | Theseus (voice) |
 Hiroki TakahashiOdysseus (voice) | Odysseus (voice) |
 Kazuhiro YamajiApollo (voice) | Apollo (voice) |
 Yuji NagataInvisible God (voice) | Invisible God (voice) |
 Rumi KazamaInvisible Goddess (voice) | Invisible Goddess (voice) |