Compulsive gambler John had finally beaten the habit, started a new life, and said farewell to Vegas for good... or so he thought. When his new boss sends him back to Sin City to investigate a shady insurance claim, all the chips are back on the table.
| Actor | Role |
|---|---|
 Steve BuscemiJohn | John |
 Romany MalcoVirgil | Virgil |
 Peter DinklageMr. Townsend | Mr. Townsend |
 Tim Blake NelsonMilitant Ned | Militant Ned |
 Sarah SilvermanJill | Jill |
 Danny TrejoBismarck | Bismarck |
 Jesse GarciaPark Ranger | Park Ranger |
 John ChoSmitty | Smitty |
| MMatthew McDuffieLucypher | Lucypher |
 Emmanuelle ChriquiTasty D Lite | Tasty D Lite |
| BBen ZellerTruck Stop Owner | Truck Stop Owner |
 Aviva BaumannPennie | Pennie |
 Shawn PrinceTicket Taker | Ticket Taker |
 Stephen EilandMordicai | Mordicai |
 Josh BerryManager | Manager |
| JJim GieslerBarker | Barker |
| IIsabel ArchuletaVegas Counter Girl | Vegas Counter Girl |
 Isaac KappyGeek | Geek |
| GGorneth D'OyleyDealer | Dealer |
| EErnest LabreckEd MacMahon Type | Ed MacMahon Type |