The Three Mesquiteers, as army scouts, soothe hostilities between the Army and Indians after both have been riled by someone with a hidden agenda - a renegade chief, who is found to be masquerading as an Army interpreter.
| Actor | Role |
|---|---|
 Robert LivingstonStony Brooke | Stony Brooke |
 Bob SteeleTucson Smith | Tucson Smith |
 Rufe DavisLullaby Joslin | Lullaby Joslin |
 Gale StormSusan Langley | Susan Langley |
 Forbes MurrayColonel Langley | Colonel Langley |
 Cornelius KeefeLieutenant Bob Manning | Lieutenant Bob Manning |
 George LynnLeRoque aka Wanechee (as Peter George Lynn) | LeRoque aka Wanechee (as Peter George Lynn) |
 Marin SaisMrs. Langley | Mrs. Langley |
 Martin FaustChief Thunder Bird (as Marty Faust) | Chief Thunder Bird (as Marty Faust) |
 Glenn StrangeLittle Bear | Little Bear |
| EEllen LoweAunt Amanda | Aunt Amanda |
 Iron Eyes CodyBlack Eagle | Black Eagle |