Join Ralph on a string of adventures after he runs away from home at the Mountain View Inn, and makes a new friend.
| Actor | Role |
|---|---|
 Fred SavageGarfield 'Garf' Jerrniga | Garfield 'Garf' Jerrniga |
 Ray WalstonMatt | Matt |
 Sara GilbertStephie | Stephie |
| JJohn Clark MatthewsRalph the Mouse (Voice) | Ralph the Mouse (Voice) |
 Conchata FerrellAunt Jill | Aunt Jill |
 Kellie MartinKaren | Karen |
 Summer PhoenixLana | Lana |
| AAnne BloomGarf's Mother | Garf's Mother |
 Bruce FrenchGarf's Father | Garf's Father |
 Hal SmithNight Clerk | Night Clerk |
 June ForaySister Mouse (Voice) | Sister Mouse (Voice) |
 Katie LeighCousin Mouse (Voice) | Cousin Mouse (Voice) |
 Corey BurtonChum (Voice) | Chum (Voice) |
 Billy BartyUncle Lester (Voice) | Uncle Lester (Voice) |
| EE'Lon CoxJonathan | Jonathan |
 Edan GrossMerton (Voice) | Merton (Voice) |