 E. G. DailyTommy Pickles (voice) | Tommy Pickles (voice) |
 Christine CavanaughChuckie Finster (voice) | Chuckie Finster (voice) |
 Cheryl ChaseAngelica Pickles (voice) | Angelica Pickles (voice) |
 Susan SarandonCoco LaBouche (voice) | Coco LaBouche (voice) |
 John LithgowJean-Claude (voice) | Jean-Claude (voice) |
 Tara StrongDil Pickles (voice) | Dil Pickles (voice) |
 Kath SoucieLil Deville / Phil DeVille / Betty DeVille (voice) | Lil Deville / Phil DeVille / Betty DeVille (voice) |
 Michael BellDrew Pickles / Chaz Finster, Sr. (voice) | Drew Pickles / Chaz Finster, Sr. (voice) |
 Cree SummerSusie Carmichael (voice) | Susie Carmichael (voice) |
 Tress MacNeilleCharlotte Pickles (voice) | Charlotte Pickles (voice) |
 Debbie ReynoldsLulu Pickles (voice) | Lulu Pickles (voice) |
 Joe AlaskeyGrandpa Lou Pickles (voice) | Grandpa Lou Pickles (voice) |
 MakoMr. Yamaguchi (voice) | Mr. Yamaguchi (voice) |
 Tim CurrySumo Singer (voice) | Sumo Singer (voice) |
 Julia KatoKira Watanabe-Finster (voice) | Kira Watanabe-Finster (voice) |
 Billy WestSumo Singer (voice) | Sumo Singer (voice) |
 Dionne QuanKimi Watanabe-Finster (voice) | Kimi Watanabe-Finster (voice) |
 Melanie ChartoffDidi Pickles (voice) | Didi Pickles (voice) |
 Casey KasemWedding DJ (voice) | Wedding DJ (voice) |
 Phil ProctorHoward DeVille (voice) | Howard DeVille (voice) |
| LLisa McClowryPrincess (voice) | Princess (voice) |
 Dan CastellanetaPriest (voice) | Priest (voice) |
 Roger RoseFinster Wedding DJ (voice) | Finster Wedding DJ (voice) |
 Kevin Michael RichardsonSumo Singer (voice) | Sumo Singer (voice) |
 Jack RileyStu Pickles (voice) | Stu Pickles (voice) |
 Charlie AdlerInspector (voice) | Inspector (voice) |
 Braden WrightCafé Owner (voice) | Café Owner (voice) |
 Charles FathyPhotographer (voice) | Photographer (voice) |
 Margaret SmithStewardess (voice) | Stewardess (voice) |
 Phillipe SimonAnimatronic Bus Driver (voice) | Animatronic Bus Driver (voice) |
