 E. G. DailyTommy Pickles (voice) | Tommy Pickles (voice) |
 Nancy CartwrightChuckie Finster (voice) | Chuckie Finster (voice) |
 Kath SouciePhil DeVille / Lil DeVille / Betty DeVille (voice) | Phil DeVille / Lil DeVille / Betty DeVille (voice) |
 Dionne QuanKimi Watanabe-Finster (voice) | Kimi Watanabe-Finster (voice) |
 Tim CurryNigel Thornberry (voice) | Nigel Thornberry (voice) |
 Joe AlaskeyLou Pickles (voice) | Lou Pickles (voice) |
 Tress MacNeilleCharlotte Pickles (voice) | Charlotte Pickles (voice) |
 Michael BellDrew Pickles / Charles 'Chaz' Finster, Sr. (voice) | Drew Pickles / Charles 'Chaz' Finster, Sr. (voice) |
 Julia KatoKira Watanabe-Finster (voice) | Kira Watanabe-Finster (voice) |
 Phil ProctorHoward DeVille (voice) | Howard DeVille (voice) |
 Jack RileyStuart 'Stu' Pickles (voice) | Stuart 'Stu' Pickles (voice) |
 Tara StrongDil Pickles (voice) | Dil Pickles (voice) |
 Cree SummerSusie Carmichael (voice) | Susie Carmichael (voice) |
 Cheryl ChaseAngelica Pickels (voice) | Angelica Pickels (voice) |
 Melanie ChartoffDidi Pickles (voice) | Didi Pickles (voice) |
 Lacey ChabertEliza Thornberry (voice) | Eliza Thornberry (voice) |
 Danielle HarrisDebbie Thornberry (voice) | Debbie Thornberry (voice) |
 Jodi CarlisleMarianne Thornberry (voice) | Marianne Thornberry (voice) |
 FleaDonnie Thornberry (voice) | Donnie Thornberry (voice) |
 Tom KaneDarwin (voice) | Darwin (voice) |
 Bruce WillisSpike (voice) | Spike (voice) |
 Tony JayDr. Lipschitz (voice) | Dr. Lipschitz (voice) |
 Ethan PhillipsToa (voice) | Toa (voice) |
 Chrissie HyndeSiri (voice) | Siri (voice) |
