Will Tommy still be the gang's fearless leader? Will Chuckie survive his first "crush"? Will Angelica still be underhanded? The answers are here as the entire Rugrats gang embarks on one of their most fantastic adventures yet.
| Actor | Role |
|---|---|
 Christine CavanaughCharles 'Chuckie' Finster Jr. (voice) | Charles 'Chuckie' Finster Jr. (voice) |
 Cheryl ChaseAngelica C. Pickles (voice) | Angelica C. Pickles (voice) |
 Kath SouciePhillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice) | Phillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice) |
 Tara StrongDylan Prescott 'Dil' Pickles (voice) | Dylan Prescott 'Dil' Pickles (voice) |
 Cree SummerSusan 'Susie' Carmichael (voice) | Susan 'Susie' Carmichael (voice) |
 Tress MacNeilleCharlotte C. Pickles (voice) | Charlotte C. Pickles (voice) |
 Melanie ChartoffDidi Pickles (voice) | Didi Pickles (voice) |
 Jack RileyStu Pickles (voice) | Stu Pickles (voice) |
 Joe AlaskeyLouis 'Grandpa' Pickles (voice) | Louis 'Grandpa' Pickles (voice) |
 Michael BellDrew Pickles/Charles 'Chaz' Finster, Sr. (voice) | Drew Pickles/Charles 'Chaz' Finster, Sr. (voice) |
 Charlie AdlerProfessor Spooky (voice) | Professor Spooky (voice) |
 E. G. DailyTommy Pickles (voice) | Tommy Pickles (voice) |