 John WayneCol. Cord McNally | Col. Cord McNally |
 Jorge RiveroCapt. Pierre Cordona | Capt. Pierre Cordona |
 Jennifer O'NeillShasta Delaney | Shasta Delaney |
 Jack ElamPhillips | Phillips |
 Christopher MitchumSgt. Tuscarora Phillips | Sgt. Tuscarora Phillips |
 Victor FrenchKetcham | Ketcham |
 Susana DosamantesMaria Carmen | Maria Carmen |
 Sherry LansingAmelita | Amelita |
 David HuddlestonDr. Ivor Jones | Dr. Ivor Jones |
 Mike HenryRio Lobo Sheriff 'Blue Tom' Hendricks | Rio Lobo Sheriff 'Blue Tom' Hendricks |
 Bill WilliamsBlackthorne Sheriff Pat Cronin | Blackthorne Sheriff Pat Cronin |
 Jim DavisRiley | Riley |
 Dean SmithBide | Bide |
 Robert DonnerWhitey Carter | Whitey Carter |
 George PlimptonGeorge, Whitey's 4th Henchman | George, Whitey's 4th Henchman |
 Edward FaulknerLt. Harris | Lt. Harris |
 Peter JasonLt. Ned Forsythe | Lt. Ned Forsythe |
 Chuck CourtneyChuck, Whitey's 2nd Henchman | Chuck, Whitey's 2nd Henchman |
| RRobert RothwellWhitey's 3rd Henchman | Whitey's 3rd Henchman |
 Don 'Red' BarryFeeny - Bartender (uncredited) | Feeny - Bartender (uncredited) |
 Sondra CurrieBlackthorne Prostitute (uncredited) | Blackthorne Prostitute (uncredited) |
 Chuck Hayward(uncredited) | (uncredited) |
| CConrad HoolBart (uncredited) | Bart (uncredited) |
| LLance HoolPicket (uncredited) | Picket (uncredited) |
 John HudkinsRio Lobo Deputy (uncredited) | Rio Lobo Deputy (uncredited) |
 Michael JeffersBarfly in Blackthorne (uncredited) | Barfly in Blackthorne (uncredited) |
| FFrank KennedyMinor Role (uncredited) | Minor Role (uncredited) |
| RRichard LaMarrMan in Army Post Saloon (uncredited) | Man in Army Post Saloon (uncredited) |
 John McKeeRio Lobo Deputy (uncredited) | Rio Lobo Deputy (uncredited) |
 Boyd 'Red' MorganTrain Engineer (uncredited) | Train Engineer (uncredited) |
