 John WayneLt. Col. Kirby Yorke | Lt. Col. Kirby Yorke |
 Maureen O'HaraMrs. Kathleen Yorke | Mrs. Kathleen Yorke |
 Ben JohnsonTrooper Travis Tyree | Trooper Travis Tyree |
 Claude Jarman Jr.Trooper Jefferson 'Jeff' Yorke | Trooper Jefferson 'Jeff' Yorke |
 Harry Carey, Jr.Trooper Daniel 'Sandy' Boone | Trooper Daniel 'Sandy' Boone |
 Chill WillsDr. Wilkins | Dr. Wilkins |
 J. Carrol NaishLt. Gen. Philip Sheridan | Lt. Gen. Philip Sheridan |
 Victor McLaglenSgt. Maj. Timothy Quincannon | Sgt. Maj. Timothy Quincannon |
 Grant WithersU.S. Deputy Marshal | U.S. Deputy Marshal |
| PPeter OrtizCapt. St. Jacques | Capt. St. Jacques |
 Steve PendletonCapt. Prescott | Capt. Prescott |
 Karolyn GrimesMargaret Mary | Margaret Mary |
 Alberto MorinLieutenant | Lieutenant |
 Stan JonesSergeant | Sergeant |
| FFred KennedyTrooper Heinze | Trooper Heinze |
 Ken CurtisDonnelly - Regimental Singer (uncredited) | Donnelly - Regimental Singer (uncredited) |
| TTommy DossRegimental Singer (uncredited) | Regimental Singer (uncredited) |
 Hugh FarrRegimental Singer (uncredited) | Regimental Singer (uncredited) |
| KKarl FarrRegimental Singer (uncredited) | Regimental Singer (uncredited) |
 Shug FisherRegimental Singer/Bugler (uncredited) | Regimental Singer/Bugler (uncredited) |
 Cliff LyonsSoldier (uncredited) | Soldier (uncredited) |
| LLee MorganMinor Role (uncredited) | Minor Role (uncredited) |
 Jack PennickSergeant (uncredited) | Sergeant (uncredited) |
 Lloyd PerrymanRegimental Singer (uncredited) | Regimental Singer (uncredited) |
 Chuck RobersonOfficer / Indian Fires Arrow Into Col. York's Chest (uncredited) | Officer / Indian Fires Arrow Into Col. York's Chest (uncredited) |
| BBarlow SimpsonIndian Chief (uncredited) | Indian Chief (uncredited) |
 Patrick WayneBoy (uncredited) | Boy (uncredited) |
