At the breaking of the Civil War the garrison of Fort Laramie splits between the sympathezers of the two different factions, but when the fort is attacked by the Sioux, they unite their forces to fight them.
| Actor | Role |
|---|---|
 John DehnerMaj. Seth Bradner | Maj. Seth Bradner |
 Gregg PalmerCapt. James 'Jamie' Tenslip | Capt. James 'Jamie' Tenslip |
 Frances HelmMelissa Bradner | Melissa Bradner |
 Don GordonJean Salignac | Jean Salignac |
 Robert KeysSgt. Darrach | Sgt. Darrach |
 Robert KnappLt. Chick Waller | Lt. Chick Waller |
 Eddie Little SkyRed Cloud | Red Cloud |
 Harry Dean StantonRinty | Rinty |
 William PhillipsSerrell | Serrell |
 Kenne DuncanCapt. Foley | Capt. Foley |
| SSterling FranckEzra | Ezra |
| CClay RandolphCaswell | Caswell |
 Jack IngramNot listed | Not listed |
| BBill ClarkNot listed | Not listed |
 Boyd 'Red' MorganNot listed | Not listed |
| EEarl ParkerNot listed | Not listed |
| BBill BarkerNot listed | Not listed |
 Fritz FordNot listed | Not listed |