Lewis, Sheriff and Tony are three friends vacationing in Malaysia. Sheriff and Tony eventually leave to pursue careers in New York, but Lewis stays behind to work with orangutans. Two years later, Sheriff and Tony learn that, because of their past actions, Lewis has been arrested for drug possession. With Lewis facing a death sentence, the friends are left with a difficult decision: return to Malaysia and split Lewis' sentence, or let him die.
| Actor | Role |
|---|---|
 Vince VaughnJohn 'Sheriff' Volgecherev | John 'Sheriff' Volgecherev |
 Anne HecheBeth Eastern | Beth Eastern |
 Joaquin PhoenixLewis McBride | Lewis McBride |
 David ConradTony Croft | Tony Croft |
 Jada Pinkett SmithM.J. Major | M.J. Major |
 Vera FarmigaKerrie | Kerrie |
 Nick SandowRavitch | Ravitch |
 Elizabeth RodriguezGaby | Gaby |
| MMing LeeMr. Chandran | Mr. Chandran |
 Joel de la FuenteMr. Doramin | Mr. Doramin |
| RRichard ChangProsecutor | Prosecutor |
 James McCauleyFamous Divorce Lawyer | Famous Divorce Lawyer |
 Brette TaylorYoung Woman in Limo | Young Woman in Limo |
| DDeanna YusoffWoman in Bar | Woman in Bar |
 David ZayasConstruction Foreman | Construction Foreman |
| IIs IssariyaMalaysian Woman in Hammock | Malaysian Woman in Hammock |
| EEd HodsonFeatures Editor | Features Editor |
 Kevin ScullinDoorman #1 | Doorman #1 |
| GGlenn PatrickDoorman #2 | Doorman #2 |
 Patrick TeohChief Justice | Chief Justice |
 Curzon DobellClient | Client |
| AAmy WongTicket Agent | Ticket Agent |