 Paul MercierLeon S. Kennedy (voice) | Leon S. Kennedy (voice) |
 Alyson CourtClaire Redfield (voice) | Claire Redfield (voice) |
 Laura BaileyAngela Miller (voice) | Angela Miller (voice) |
 Roger Craig SmithCurtis Miller (voice) | Curtis Miller (voice) |
 Crispin FreemanFrederic Downing (voice) | Frederic Downing (voice) |
 Michael SorichSenator Ron Davis (voice) | Senator Ron Davis (voice) |
 Salli SaffiotiIngrid Hunnigan (voice) | Ingrid Hunnigan (voice) |
 Michelle RuffRani Chawla (voice) | Rani Chawla (voice) |
 Mary Elizabeth McGlynnRani's aunt (voice) | Rani's aunt (voice) |
 Steve BlumGreg Glenn (voice) | Greg Glenn (voice) |
 Michael McConnohieWilPharma CEO (voice) | WilPharma CEO (voice) |
 Kirk ThorntonU.S. President (voice) | U.S. President (voice) |
 Cindy RobinsonVarious (voice) | Various (voice) |
 Dave WittenbergVarious (voice) | Various (voice) |
 Kari WahlgrenVarious (voice) | Various (voice) |
 Kyle HebertVarious (voice) | Various (voice) |
 Barbara GoodsonVarious (voice) | Various (voice) |
 Keith SilversteinVarious (voice) | Various (voice) |
 Yuri LowenthalVarious (voice) | Various (voice) |
 Megan HollingsheadVarious (voice) | Various (voice) |
 Skip StellrechtVarious (voice) | Various (voice) |
 Troy BakerVarious (voice) | Various (voice) |
 Karen StrassmanVarious (voice) | Various (voice) |
 JB BlancVarious (voice) | Various (voice) |
 Johnny Yong BoschVarious (voice) | Various (voice) |
 Derek MearsGreg Glenn / G-Curtis (motion capture) | Greg Glenn / G-Curtis (motion capture) |
