Based on the comic strip by Gene Byrnes, the "Reg'lar Fellers", and one girl-feller, tinker with building a land/water machine, form a kid-band and go on the radio, celebrate a birthday, get involved with gangsters...and reunite a wealthy recluse with her baby granddaughter and estranged daughter-in-law.
| Actor | Role |
|---|---|
 Billy LeePinhead Duffy | Pinhead Duffy |
 Carl SwitzerBump Hudson | Bump Hudson |
| BBuddy BolesJimmy Dugan | Jimmy Dugan |
| JJanet DempseyAggie Reilly | Aggie Reilly |
| HHenry 'Spike' LeeSkeeter | Skeeter |
| MMalcolm HuttonPuddin' Head Duffy | Puddin' Head Duffy |
 Sarah PaddenHetty Carter | Hetty Carter |
 Roscoe AtesEmory McQuade | Emory McQuade |
| DDanna CallahanJane Watson | Jane Watson |
| DDiane WareHazel Barry | Hazel Barry |
| LLeonard GrassiiWarren Hamilton | Warren Hamilton |
| SSharon LynneBaby Carter | Baby Carter |
| MMaren MayoCaroline Carter | Caroline Carter |
| NNetta PackerMartha | Martha |
| JJack C. SmithOfficer Flynn | Officer Flynn |
 Marguerite De La MotteMrs. Dugan | Mrs. Dugan |
 Pat O'MalleyMr. Dugan Sr. | Mr. Dugan Sr. |
| AAnna Ruth HughesMolly Dugan | Molly Dugan |
| DDan StowellFerrel | Ferrel |
| DDaisy FordMrs. Duffy | Mrs. Duffy |
 Herb VigranMr. Hall, Radio Announcer | Mr. Hall, Radio Announcer |