 James Arnold TaylorRatchet (voice) | Ratchet (voice) |
 David KayeClank (voice) | Clank (voice) |
 Jim WardCaptain Qwark (voice) | Captain Qwark (voice) |
 Paul GiamattiChairman Drek (voice) | Chairman Drek (voice) |
 Armin ShimermanDr. Nefarious (voice) | Dr. Nefarious (voice) |
 Rosario DawsonElaris (voice) | Elaris (voice) |
 Bella ThorneCora Veralux (voice) | Cora Veralux (voice) |
 Vincent TongBrax / Solana Trooper (voice) | Brax / Solana Trooper (voice) |
 Andrew CowndenZed / Blarg (voice) | Zed / Blarg (voice) |
 Sylvester StalloneVictor Von Ion (voice) | Victor Von Ion (voice) |
 John GoodmanGrimroth (voice) | Grimroth (voice) |
 Lee TockarMr. Micron (voice) | Mr. Micron (voice) |
 Brian DobsonDallas Wannamaker / Announcer / Drek Computer (voice) | Dallas Wannamaker / Announcer / Drek Computer (voice) |
 Tabitha St. GermainJuanita Alvaro (voice) | Juanita Alvaro (voice) |
 Brad SwaileOllie / Super Fan (voice) | Ollie / Super Fan (voice) |
 Brian DrummondInspectobot / Warbot / Zurkons (voice) | Inspectobot / Warbot / Zurkons (voice) |
| CCole HowardBlarg (voice) | Blarg (voice) |
 Ian James CorlettBlarg (voice) | Blarg (voice) |
 Alessandro JulianiSolana Trooper (voice) | Solana Trooper (voice) |
 Rebecca ShoichetStanley's Mom / Ship Computer (voice) | Stanley's Mom / Ship Computer (voice) |
| DDon BriggsStarship Commander (voice) | Starship Commander (voice) |
