 Johnny DeppRango / Lars (voice) | Rango / Lars (voice) |
 Isla FisherBeans (voice) | Beans (voice) |
 Ned BeattyMayor (voice) | Mayor (voice) |
 Bill NighyRattlesnake Jake (voice) | Rattlesnake Jake (voice) |
 Abigail BreslinPriscilla (voice) | Priscilla (voice) |
 Alfred MolinaRoadkill (voice) | Roadkill (voice) |
 Stephen RootDoc / Merrimack / Mr. Snuggles (voice) | Doc / Merrimack / Mr. Snuggles (voice) |
 Harry Dean StantonBalthazar (voice) | Balthazar (voice) |
 Timothy OlyphantSpirit of the West (voice) | Spirit of the West (voice) |
 Ray WinstoneBad Bill (voice) | Bad Bill (voice) |
 Ian AbercrombieAmbrose (voice) | Ambrose (voice) |
 Gil BirminghamWounded Bird (voice) | Wounded Bird (voice) |
 James Ward ByrkitWaffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice) | Waffles / Gordy / Papa Joad / Cousin Murt / Curlie / Knife Attacker / Rodent Kid (voice) |
 Claudia BlackAngelique (voice) | Angelique (voice) |
 Blake ClarkBuford (voice) | Buford (voice) |
 John CothranElgin (voice) | Elgin (voice) |
 Patrika DarboDelilah / Maybelle (voice) | Delilah / Maybelle (voice) |
 George DelHoyoSeñor Flan - Mariachi Accordion (voice) | Señor Flan - Mariachi Accordion (voice) |
 Maile FlanaganLucky (voice) | Lucky (voice) |
 Charles FleischerElbows (voice) | Elbows (voice) |
 Beth GrantBonnie (voice) | Bonnie (voice) |
 Ryan HurstJedidiah (voice) | Jedidiah (voice) |
 Vincent KartheiserEzekiel / Lasso Rodent (voice) | Ezekiel / Lasso Rodent (voice) |
 Hemky MaderaChorizo (voice) | Chorizo (voice) |
 Alex ManugianSpoons (voice) | Spoons (voice) |
 Mark 'Crash' McCreeryParsons (voice) | Parsons (voice) |
 Joe NuñezRock-Eye (voice) | Rock-Eye (voice) |
 Christopher Lee ParsonHazel / Kinski / Stump / Clinker / Lenny / Boseefus / Dirt Kid (voice) | Hazel / Kinski / Stump / Clinker / Lenny / Boseefus / Dirt Kid (voice) |
 Lew TempleFurgus / Hitch (voice) | Furgus / Hitch (voice) |
 Alanna UbachBoo / Cletus / Fresca / Miss Daisy (voice) | Boo / Cletus / Fresca / Miss Daisy (voice) |
