Driven to the brink by her overworked and insensitive husband and horrendously selfish children, Brooklyn-based housewife Gloria Goodman seeks a meaning to life.
| Actor | Role |
|---|---|
 Kirstie AlleyGloria Goodman | Gloria Goodman |
 Clancy BrownAl Goodman | Al Goodman |
 Gil BellowsBert Kramer | Bert Kramer |
 Laraine NewmanFlo | Flo |
 Adam LambergStewie Goodman | Stewie Goodman |
 Tori McPetrieSherry Goodman | Sherry Goodman |
| JJordan HughesOscar | Oscar |
 Monica ParkerGoldie | Goldie |
 Maria VacratsisSylvia | Sylvia |
| MMyra FriedHarriet | Harriet |
 Fab FilippoJohnny | Johnny |
 Harvey AtkinMr. Lewis | Mr. Lewis |
 Sally CahillRuthie | Ruthie |
| DDick CallahanPete | Pete |
| JJohn E. CampbellSheldon | Sheldon |
| JJason DeParisAngelo | Angelo |
| BBenji DetskyMickey | Mickey |
 Victor ErtmanisNat | Nat |
 Ernie GrunwaldHarvey | Harvey |
 Tony ShalhoubNarrator | Narrator |
 Dov TiefenbachJoel | Joel |
 Michael VollansButch | Butch |
 Heidi von PalleskeMildred | Mildred |
| JJason WodlingerEddie | Eddie |
 Tony NappoMoving Man #2 | Moving Man #2 |