 Antonio BanderasPuss in Boots (voice) | Puss in Boots (voice) |
 Salma Hayek PinaultKitty Softpaws (voice) | Kitty Softpaws (voice) |
 Harvey GuillénPerrito (voice) | Perrito (voice) |
 Wagner MouraWolf (voice) | Wolf (voice) |
 Florence PughGoldilocks (voice) | Goldilocks (voice) |
 Olivia ColmanMama Bear (voice) | Mama Bear (voice) |
 Ray WinstonePapa Bear (voice) | Papa Bear (voice) |
 Samson KayoBaby Bear (voice) | Baby Bear (voice) |
 John MulaneyJack Horner (voice) | Jack Horner (voice) |
 Da'Vine Joy RandolphMama Luna (voice) | Mama Luna (voice) |
 Anthony MendezDoctor (voice) | Doctor (voice) |
 Kevin McCannEthical Bug (voice) | Ethical Bug (voice) |
 Bernardo de PaulaGovernor / Little Boy's Father / Male Partier (voice) | Governor / Little Boy's Father / Male Partier (voice) |
 Betsy SodaroJo Serpent / Additional Baker's Dozen Gang Member (voice) | Jo Serpent / Additional Baker's Dozen Gang Member (voice) |
 Artemis PebdaniJan Serpent (voice) | Jan Serpent (voice) |
 Conrad VernonGingy (voice) | Gingy (voice) |
 Cody CameronPinocchio (voice) | Pinocchio (voice) |
 Kailey CrawfordLittle Goldi (voice) | Little Goldi (voice) |
 Al RodrigoBartender (voice) | Bartender (voice) |
 Bob PersichettiOhhh Cat (voice) | Ohhh Cat (voice) |
 Miguel MatraiLittle Boy (voice) | Little Boy (voice) |
 Pilar UribeGovernor's Assistant / Female Partier (voice) | Governor's Assistant / Female Partier (voice) |
 Heidi GardnerLast Baker (voice) | Last Baker (voice) |
 Joel CrawfordBand Member / Baker's Dozen Gang Member (voice) | Band Member / Baker's Dozen Gang Member (voice) |
 Januel MercadoBand Member / Baker's Dozen Gang Member (voice) | Band Member / Baker's Dozen Gang Member (voice) |
 James RyanLittle Jack Audience Member / Baker's Dozen Gang Member (voice) | Little Jack Audience Member / Baker's Dozen Gang Member (voice) |
| NNatalia CronemboldWaitress / Baker's Dozen Gang Member (voice) | Waitress / Baker's Dozen Gang Member (voice) |
 Paul FisherAdditional Baker's Dozen Gang Member (voice) | Additional Baker's Dozen Gang Member (voice) |
 Aydrea WaldenAdditional Baker's Dozen Gang Member (voice) | Additional Baker's Dozen Gang Member (voice) |
