 Lionel BarrymoreDr. Josiah Glass | Dr. Josiah Glass |
 Jean ArthurMaria Theresa 'Terry' O'Reilly | Maria Theresa 'Terry' O'Reilly |
 Chester MorrisJeff Crane | Jeff Crane |
 Joseph CalleiaSonny 'Dinkie' Black | Sonny 'Dinkie' Black |
 Paul KellySpecial Agent James Duff | Special Agent James Duff |
 Lewis StonePrison Warden | Prison Warden |
| PPaul HurstRufe Parker | Rufe Parker |
 George E. StoneButch | Butch |
| SSam BakerMose Jones | Mose Jones |
 William BaileyFederal Agent (uncredited) | Federal Agent (uncredited) |
 Brooks BenedictBar Patron (uncredited) | Bar Patron (uncredited) |
 Ed BradyConvict in Prison (uncredited) | Convict in Prison (uncredited) |
 Lane ChandlerTrain Conductor (uncredited) | Train Conductor (uncredited) |
 Cora Sue CollinsLittle Girl (uncredited) | Little Girl (uncredited) |
 Helene CostelloConvict Wife (uncredited) | Convict Wife (uncredited) |
 Nell CraigDuff's Secretary with Telegram (uncredited) | Duff's Secretary with Telegram (uncredited) |
 Frank DarienDr. Hale - Plastic Surgeon (uncredited) | Dr. Hale - Plastic Surgeon (uncredited) |
 James FlavinFlavin - Federal Agent (uncredited) | Flavin - Federal Agent (uncredited) |
| HHarry GeiseConvict (uncredited) | Convict (uncredited) |
 John GeorgeConvict (uncredited) | Convict (uncredited) |
 Jonathan HalePrison Board Member (uncredited) | Prison Board Member (uncredited) |
 Henry HallRestaurant Patron (uncredited) | Restaurant Patron (uncredited) |
 Lillian HarmerMrs. Higgins (uncredited) | Mrs. Higgins (uncredited) |
| EEddie HartEddie - Sonny's Henchman (uncredited) | Eddie - Sonny's Henchman (uncredited) |
 Edward HearnPoliceman in Pursuing Car (uncredited) | Policeman in Pursuing Car (uncredited) |
 Al HillAl - Sonny's Henchman (uncredited) | Al - Sonny's Henchman (uncredited) |
 Arthur HousmanScottsdale Bar Drunk (uncredited) | Scottsdale Bar Drunk (uncredited) |
 William IrvingFederal Agent (uncredited) | Federal Agent (uncredited) |
 Selmer JacksonSimpson - Prison Board Member (uncredited) | Simpson - Prison Board Member (uncredited) |
 Gladden JamesFederal Agent (uncredited) | Federal Agent (uncredited) |
