Ma Barker and her sons rob banks, shoot people and wind up at the top of the FBI's Most Wanted list in the 1930s.
| Actor | Role |
|---|---|
 Theresa RussellKate Barker | Kate Barker |
 Eric RobertsArthur Dunlop | Arthur Dunlop |
 Alyssa MilanoAmaryllis | Amaryllis |
 James MarsdenDoc Barker | Doc Barker |
 Richard EdenGeorge Barker | George Barker |
 Joe DainLloyd Barker | Lloyd Barker |
 Dan CorteseMelvin Purvis | Melvin Purvis |
 Frank Stallone Jr.Alvin Karpis | Alvin Karpis |
| LLeah BestYoung Kate | Young Kate |
| CChip HellerMr. Clarke | Mr. Clarke |
 Tom WardPaymaster | Paymaster |
| TTerry D. SeagoTall Sheriff | Tall Sheriff |
 Brian PeckJ. Edgar Hoover | J. Edgar Hoover |
 Grant CramerSam Cowley | Sam Cowley |
 Rex LinnAl Spencer | Al Spencer |
| BBrendan WilliamsRacine Burdett | Racine Burdett |
| EEd DollisonMr. Harris | Mr. Harris |
| MMichael StadvecMan in Honky Tonk | Man in Honky Tonk |
 Gary SieversDoctor | Doctor |
 Gavin HarrisonFreddie Barker | Freddie Barker |