Wild Bill Hickok (Bill Elliott) leads a wagon train of settlers from Kansas to Colorado. Along the way, they cross a group of Indians who don't want any more settlers on their land.
| Actor | Role |
|---|---|
 Bill Elliott'Wild' Bill Hickok | 'Wild' Bill Hickok |
| EEvelyn YoungVirginia Benton | Virginia Benton |
 Dub TaylorCannonball | Cannonball |
 Kenneth HarlanDalton Stull | Dalton Stull |
 Ray TealWolf Tanner | Wolf Tanner |
 Bob BurnsJim Gibbs | Jim Gibbs |
| NNetta PackerCora Gibbs | Cora Gibbs |
 Richard FiskeAdams | Adams |
 Edmund CobbBlacksmith Rusty | Blacksmith Rusty |
 Jim ThorpeChief Sanche | Chief Sanche |