 Richard BenjaminAlexander Portnoy | Alexander Portnoy |
 Karen BlackMary Jane Reid a.k.a. Monkey | Mary Jane Reid a.k.a. Monkey |
 Lee GrantSophie Portnoy | Sophie Portnoy |
 Jack SomackJack Portnoy | Jack Portnoy |
 Renée LippinHannah Portnoy | Hannah Portnoy |
 Jeannie BerlinBubbles Girardi | Bubbles Girardi |
 Kevin ConwaySmolka | Smolka |
 Lewis J. StadlenMandel (as Lewis Stadlen) | Mandel (as Lewis Stadlen) |
 Jill ClayburghNaomi | Naomi |
| JJessica RainsOpening Girl | Opening Girl |
 Francesca De SapioLina, Rome Prostitute | Lina, Rome Prostitute |
| WWilliam PabstClerk at Inn | Clerk at Inn |
 Eleanor ZeeWoman in Hospital Bed | Woman in Hospital Bed |
| TTony BrandeCab Driver | Cab Driver |
| DD.P. BarnesDr. Spielvogel | Dr. Spielvogel |
 John CarradineJudge (voice) (uncredited) | Judge (voice) (uncredited) |
| AArline BletcherElevator Lady #2 (uncredited) | Elevator Lady #2 (uncredited) |
 Minta DurfeeElevator Lady #1 (uncredited) | Elevator Lady #1 (uncredited) |
| MMike De AndaMr. Harero (uncredited) | Mr. Harero (uncredited) |
 John P. DulaneyBackground (uncredited) | Background (uncredited) |
| BBurt RichardsStreet Vendor (uncredited) | Street Vendor (uncredited) |
| DDarryl SeamenAlexander, Age 8 (uncredited) | Alexander, Age 8 (uncredited) |
| YYaffa SharirStewardess (uncredited) | Stewardess (uncredited) |
 Carmen ZapataMrs. Harero (uncredited) | Mrs. Harero (uncredited) |
