In this short, a youthful Buffalo Bill Cody joins the newly-formed Pony Express as a station hand and replaces the regular rider when he is shot.
| Actor | Role |
|---|---|
 George ReevesWilliam F. 'Buffalo Bill' Cody | William F. 'Buffalo Bill' Cody |
 David BruceJohnny Frey | Johnny Frey |
 Frank WilcoxBolliver Roberts | Bolliver Roberts |
 J. Farrell MacDonaldNevada Jim | Nevada Jim |
| JJoe KingColonel Joseph Randall | Colonel Joseph Randall |
 Addison RichardsTipton Walton | Tipton Walton |