Buffalo Bill and Wild Bill Hickok join forces to establish a mail route that can get mail from St. Joseph, Missouri, to Sacramento, California, in ten days. Along the way they must battle bad weather, hostile Indians and outlaws intent on robbing the mail and shutting down the entire operation.
| Actor | Role |
|---|---|
 Charlton HestonCaptain William Frank 'Buffalo Bill' Cody | Captain William Frank 'Buffalo Bill' Cody |
 Rhonda FlemingEvelyn Hastings | Evelyn Hastings |
 Jan SterlingDenny Russell | Denny Russell |
 Forrest TuckerJames Butler aka Wild Bill Hickok | James Butler aka Wild Bill Hickok |
 Porter HallJim Bridger | Jim Bridger |
 Henry BrandonJoe Cooper | Joe Cooper |
 Richard ShannonRed Barrett | Red Barrett |
 Stuart RandallPemberton | Pemberton |
 Lewis MartinSgt. Russell | Sgt. Russell |
 Pat HoganChief Yellow Hand (uncredited) | Chief Yellow Hand (uncredited) |
 Michael MooreRance Hastings | Rance Hastings |
 Frank WilcoxMr. Walstron (uncredited) | Mr. Walstron (uncredited) |
| AArt FelixTownsman (uncredited) | Townsman (uncredited) |
 Chet BrandenburgTownsman (uncredited) | Townsman (uncredited) |
 Harry TenbrookTownsman (uncredited) | Townsman (uncredited) |
| CChick HannanTownsman (uncredited) | Townsman (uncredited) |
| GGeorge BellTownsman (uncredited) | Townsman (uncredited) |