When disc jockey Grant Mazzy reports to his basement radio station in the Canadian town of Pontypool, he thinks it's just another day at work. But when he hears reports of a virus that turns people into zombies, Mazzy barricades himself in the radio booth and tries to figure out a way to warn his listeners about the virus and its unlikely mode of transmission.
| Actor | Role |
|---|---|
 Stephen McHattieGrant Mazzy | Grant Mazzy |
 Lisa HouleSydney Briar | Sydney Briar |
 Georgina ReillyLaurel-Ann Drummond | Laurel-Ann Drummond |
 Hrant AlianakDr. Mendez | Dr. Mendez |
 Rick RobertsKen Loney (voice) | Ken Loney (voice) |
 Daniel FathersNigel Healing | Nigel Healing |
 Beatriz YusteNancy Freethy | Nancy Freethy |
 Boyd BanksJay (Osama) | Jay (Osama) |
 Hannah FlemingMaureen (Farraj) | Maureen (Farraj) |
 Laura NordinSpooky Woman | Spooky Woman |
| RRachel BurnsColleen (Daud) | Colleen (Daud) |
 Tony BurgessTony (Lawrence) | Tony (Lawrence) |
 Louis NeginConversationalist | Conversationalist |
| DDiane GordonConversationalist | Conversationalist |
 Daniel Junghuan ParkConversationalist | Conversationalist |