 Hayley MillsPollyanna | Pollyanna |
 Jane WymanAunt Polly | Aunt Polly |
 Richard EganDr. Edmond Chilton | Dr. Edmond Chilton |
 Karl MaldenReverend Paul Ford | Reverend Paul Ford |
 Nancy OlsonNancy Furman | Nancy Furman |
 Adolphe MenjouMr. Pendergast | Mr. Pendergast |
 Donald CrispMayor Karl Warren | Mayor Karl Warren |
 Agnes MooreheadMrs. Snow | Mrs. Snow |
 Kevin CorcoranJimmy Bean | Jimmy Bean |
 James DruryGeorge Dodds | George Dodds |
 Reta ShawTillie Lagerlof | Tillie Lagerlof |
 Leora DanaMrs. Ford | Mrs. Ford |
 Anne SeymourAmelia Tarbell | Amelia Tarbell |
 Edward PlattBen Tarbell | Ben Tarbell |
 Mary Grace CanfieldAngelica | Angelica |
 Jenny EganMildred Snow | Mildred Snow |
 Gage ClarkeMr. Murg | Mr. Murg |
 Ian WolfeMr. Neely | Mr. Neely |
 Nolan LearyMr. Thomas | Mr. Thomas |
 Edgar DearingMr. Gorman | Mr. Gorman |
 Arthur ToveyFishing Booth Attendant (Uncredited) | Fishing Booth Attendant (Uncredited) |
 Paul FreesBarker (Voice) (Uncredited) | Barker (Voice) (Uncredited) |
| JJack DeeryTownsman (Uncredited) | Townsman (Uncredited) |
| SStephanie GormanGirl Singing 'America, America' (Uncredited) | Girl Singing 'America, America' (Uncredited) |
| TTim GrahamOrphanage Worker (Uncredited) | Orphanage Worker (Uncredited) |
 Signe HackTownswoman (Uncredited) | Townswoman (Uncredited) |
 Harry HarveyEditor (Uncredited) | Editor (Uncredited) |
| HHarvey KarelsParty Guest (Uncredited) | Party Guest (Uncredited) |
 Jon LormerMr. Geary (Uncredited) | Mr. Geary (Uncredited) |
| HHans MoebusMcEnerney, Dress Shop Manager (Uncredited) | McEnerney, Dress Shop Manager (Uncredited) |
