After accepting an invitation from a mysterious trainer, Ash, Misty and Brock meet Mewtwo, an artificially created Pokémon who wants to do battle.
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After accepting an invitation from a mysterious trainer, Ash, Misty and Brock meet Mewtwo, an artificially created Pokémon who wants to do battle.
| Actor | Role |
|---|---|
 Rica MatsumotoSatoshi (voice) | Satoshi (voice) |
 Ikue OtaniPikachu (voice) | Pikachu (voice) |
 Mayumi IzukaKasumi (voice) | Kasumi (voice) |
 Satomi KorogiTogepi (voice) | Togepi (voice) |
 Yuji UedaTakeshi (voice) | Takeshi (voice) |
 Megumi HayashibaraMusashi (voice) | Musashi (voice) |
 Shin-ichiro MikiKojiro (voice) | Kojiro (voice) |
 Inuko InuyamaNyarth (voice) | Nyarth (voice) |
 Chika FujimuraJoy (voice) | Joy (voice) |
 Chinami NishimuraJunsar (voice) | Junsar (voice) |
 Kenta MiyakeSakaki (voice) | Sakaki (voice) |
 Unsho IshizukaNarrator (voice) | Narrator (voice) |
 Masachika IchimuraMewtwo (voice) | Mewtwo (voice) |
 Koichi YamaderaMew (voice) | Mew (voice) |
 Hiroshi KamiyaSorao (voice) | Sorao (voice) |
 Ayane SakuraSweet (voice) | Sweet (voice) |
 Hiroyuki YoshinoUmio (voice) | Umio (voice) |
 Sachiko KobayashiVoyager (voice) | Voyager (voice) |
| RRaymond JohnsonRaymond (voice) | Raymond (voice) |
 Minoru InabaDr. Fuji (voice) | Dr. Fuji (voice) |