During the Mayflower pilgrims' long voyage across the Atlantic Ocean on their way to America, Captain Christopher Jones falls in love with William Bradford's wife Dorothy.
| Actor | Role |
|---|---|
 Spencer TracyCapt. Christopher Jones | Capt. Christopher Jones |
 Gene TierneyDorothy Bradford | Dorothy Bradford |
 Van JohnsonJohn Alden | John Alden |
 Leo GennWilliam Bradford | William Bradford |
 Dawn AddamsPriscilla Mullins | Priscilla Mullins |
 Lloyd BridgesCoppin | Coppin |
 Barry JonesWilliam Brewster | William Brewster |
 John DehnerGilbert Winslow | Gilbert Winslow |
 Tommy IvoWilliam Button | William Button |
 Lowell GilmoreEdward Winslow | Edward Winslow |
 Noel DraytonMiles Standish | Miles Standish |
 Arthur ToveySettler | Settler |
| PPatrick WhyteEllis | Ellis |
 Elizabeth HarrowerElizabeth Hopkins | Elizabeth Hopkins |
 Rhys WilliamsMr. Weston | Mr. Weston |
 Dennis HoeyHead Constable | Head Constable |
 Don DillawayStephen Hopkins | Stephen Hopkins |
 Matt MooreWilliam Mullins | William Mullins |
 Paul CavanaghJohn Carver | John Carver |
 Kathleen LockhartMary Brewster | Mary Brewster |