The once clean and healthy city of Toronto becomes the pariah of the western world when a deadly chain of infection lands in the city. Panic spreads as the number of SARS cases increases as there are no effective treatments.
| Actor | Role |
|---|---|
 Kari MatchettAmy | Amy |
 Ron WhiteDr. Royce | Dr. Royce |
 Rick RobertsJeremy Neville | Jeremy Neville |
| LLannette NewRosie | Rosie |
 Rahnuma PanthakyLaura Weston | Laura Weston |
 Merwin MondesirRob Connell | Rob Connell |
 Brian MarkinsonWilson | Wilson |
 James GallandersNot listed | Not listed |
 Leslie CarlsonNot listed | Not listed |
 Alina LeeRosie's Mother | Rosie's Mother |
 Grace Lynn KungApril | April |
 James McGowanEd | Ed |
 Grahame WoodPaul | Paul |
| DDavid DunbarFranz | Franz |
 Alexandra CastilloAline | Aline |
 Eddie Max HubandScotty | Scotty |
 Niamh WilsonLindsay | Lindsay |
| MMichael FletcherBrian Mckenna | Brian Mckenna |
 Marcia BennettBabs Polaski | Babs Polaski |
 Paul EssiembreBill Polaski | Bill Polaski |
| LLucy Lee-SuiLo Kwan | Lo Kwan |
 George ChiangTom Kwan | Tom Kwan |
| WWendy LumTom Kwan's Wife | Tom Kwan's Wife |
| PPearl LamTom Kwan's Sister | Tom Kwan's Sister |
| CCito BacalsoRogelio Dagdag | Rogelio Dagdag |
 Simon SinnDr. Cheng | Dr. Cheng |
 Leslie FerreiraAngela | Angela |
| SSamantha SlanMaggie | Maggie |
 Arlene DuncanBrenda | Brenda |
| MMichael LytleBus Driver | Bus Driver |