 Vincent MartellaPhineas Flynn (voice) | Phineas Flynn (voice) |
 Thomas Brodie-SangsterFerb Fletcher (voice) | Ferb Fletcher (voice) |
 Ashley FrenchCandace Flynn (voice) | Candace Flynn (voice) |
 Dee Bradley BakerPerry the Platypus (voice) | Perry the Platypus (voice) |
 Dan PovenmireDr. Heinz Doofenshmirtz (voice) / Additional Voices | Dr. Heinz Doofenshmirtz (voice) / Additional Voices |
 Maulik PancholyBaljeet Tjinder (voice) | Baljeet Tjinder (voice) |
 Bobby GaylorBuford Van Stomm (voice) | Buford Van Stomm (voice) |
 Alyson StonerIsabella Garcia-Shapiro (voice) | Isabella Garcia-Shapiro (voice) |
 Travis WillinghamThor (voice) | Thor (voice) |
 Adrian PasdarTony Stark / Iron Man (voice) | Tony Stark / Iron Man (voice) |
 Drake BellPeter Parker / Spider-Man (voice) | Peter Parker / Spider-Man (voice) |
 Fred TatascioreHulk (voice) | Hulk (voice) |
 Liam O'BrienRed Skull (voice) | Red Skull (voice) |
 Charlie AdlerM.O.D.O.K. (voice) | M.O.D.O.K. (voice) |
 Danny TrejoVenom (voice) | Venom (voice) |
 Peter StormareWhiplash (voice) | Whiplash (voice) |
 Caroline RheaLinda Flynn-Fletcher (voice) | Linda Flynn-Fletcher (voice) |
 Richard O'BrienLawrence Fletcher (voice) | Lawrence Fletcher (voice) |
 Chi McBrideNick Fury (voice) | Nick Fury (voice) |
 Jeff 'Swampy' MarshFrancis Major Monogram / Gordon Gutsofanemu / Additional Voices | Francis Major Monogram / Gordon Gutsofanemu / Additional Voices |
 Tyler Alexander MannCarl (voice) | Carl (voice) |
 John VienerNorm (voice) | Norm (voice) |
 Stan LeeNY Hotdog Vendor / Narrator (voice) | NY Hotdog Vendor / Narrator (voice) |
 Jack McBrayerIrving DuBois (voice) | Irving DuBois (voice) |
 Kelly HuJapanese Announcer / Additional voices | Japanese Announcer / Additional voices |
| AAllie Mac KayLittle Old Lady | Little Old Lady |
