On the day of their Father's 70th birthday party, four siblings come to terms with the publication of a novel written by the youngest sibling, that exposes the family's most intimate secrets.
| Actor | Role |
|---|---|
 Michael C. HallJack | Jack |
 Sarah SilvermanCheri | Cheri |
 Rainn WilsonJoel | Joel |
 Ben SchwartzNathan | Nathan |
 Kate MaraMeg | Meg |
 Taraji P. HensonMary | Mary |
 Judy GreerLaura | Laura |
 Alicia WittAmy | Amy |
 Ron RifkinHenry Meyerwitz | Henry Meyerwitz |
 Lesley Ann WarrenMarilyn | Marilyn |
 Octavia SpencerAlison | Alison |
 Rich DeliaWaiter | Waiter |
 Stephen TobolowskyEphraim | Ephraim |
 Lewis BlackNarrator (voice) | Narrator (voice) |
 Kulap VilaysackLily | Lily |
| NNiko NovickParamedic (uncredited) | Paramedic (uncredited) |
 Nicholas HormannTed | Ted |
| MMichael McDonaldBritish Director | British Director |
 Troian BellisarioFilm Set P.A. | Film Set P.A. |
 David PackerEli | Eli |
 Danay GarcíaAttractive P.A. | Attractive P.A. |
 Deborah PrattCassandra Williamson | Cassandra Williamson |
 Michael CavanaughBrad Thompkins | Brad Thompkins |
| MMichael ChinyamurindiMaduk | Maduk |
| PPaige OrrCarly | Carly |
 Geoffrey ArendDr. Novak | Dr. Novak |
 Dominic FloresSalvador | Salvador |
 Guillermo DíazJesus | Jesus |
 Lester SpeightWizdom | Wizdom |
 Jack PlotnickBookstore Manager | Bookstore Manager |