The interwoven stories of three couples which are forced to make life-altering decisions in the face of a disastrous war. Inspired and sometimes blinded by their love, Len, Mia, Andy, Esther, Anna and Erik are as flawed and beautiful as any of the billions who are facing this human-made biological disaster.
| Actor | Role |
|---|---|
 Josh HartnettLen | Len |
 Teresa PalmerAnna | Anna |
 Alexis BledelSarah | Sarah |
 Rosario DawsonMia | Mia |
 Penn BadgleyErik | Erik |
 Gena RowlandsEsther | Esther |
 Frank LangellaAndy | Andy |
 Hill HarperRick | Rick |
| SStephen SowanJabe | Jabe |
| RReis CiaramitaroTerran | Terran |
| VValerie HurtTracy | Tracy |
 Conor LeslieDes | Des |
| SSonya A. AvakianCarol Goto | Carol Goto |
| HHolly WinglerJess | Jess |
| CCarl Noel KingJacob | Jacob |
| MMike CareyHank | Hank |
| TTheo WilliamsonMuscle | Muscle |
| GGeorge AvgoustisLawyer | Lawyer |
| EEvelyn Joy PointerLaw Form Party Laby | Law Form Party Laby |
| MMia DiazGirl in The Future | Girl in The Future |
 Chad MorganMother in The Future | Mother in The Future |
 Richard GillilandAnchor 1 | Anchor 1 |
 Greg CromerReporter 1 | Reporter 1 |
| JJeff MichaelAnchor 2 | Anchor 2 |
 Nazneen ContractorJustine Prest | Justine Prest |
 Ned VaughnCDC Spokesman | CDC Spokesman |
| DDonna DavidsonReligious Woman | Religious Woman |
| JJoe CiprianoNews Reporter | News Reporter |
 Robin Atkin DownesNews Reporter | News Reporter |
| SS. Leslie JulianNews Reporter | News Reporter |