 Richard WidmarkLt. Cmdr. Clinton 'Clint' Reed M.D. | Lt. Cmdr. Clinton 'Clint' Reed M.D. |
 Paul DouglasCapt. Tom Warren | Capt. Tom Warren |
 Barbara Bel GeddesNancy Reed | Nancy Reed |
 Jack PalanceBlackie | Blackie |
 Zero MostelRaymond Fitch | Raymond Fitch |
 Dan RissNeff - Newspaper Reporter | Neff - Newspaper Reporter |
 Tommy CookVince Poldi - Younger Brother | Vince Poldi - Younger Brother |
| WWilson Bourg Jr.Charlie - Sailor (uncredited) | Charlie - Sailor (uncredited) |
| BBeverly C. BrownDr. Mackey - Board of Health (uncredited) | Dr. Mackey - Board of Health (uncredited) |
 Lewis CharlesKochak - Murder Victim (uncredited) | Kochak - Murder Victim (uncredited) |
| HHerman CottmanOfficer Scott - Police Lab (uncredited) | Officer Scott - Police Lab (uncredited) |
| JJohn DavidFruit Salesman (uncredited) | Fruit Salesman (uncredited) |
| WWilliam A. DeanCortelyou (uncredited) | Cortelyou (uncredited) |
| RRobert DorsenCoast Guard Lieutenant (uncredited) | Coast Guard Lieutenant (uncredited) |
| GGeorge EhmigKleber - Medical Examiner Technician (uncredited) | Kleber - Medical Examiner Technician (uncredited) |
| HH. Waller Fowler Jr.Mayor Murray (uncredited) | Mayor Murray (uncredited) |
| PPaul HostetlerLt. Paul Gafney M.D. - Public Health Service (uncredited) | Lt. Paul Gafney M.D. - Public Health Service (uncredited) |
 Elia KazanCleaver - Mortuary Assistant (uncredited) | Cleaver - Mortuary Assistant (uncredited) |
| EEdward KennedyJordan (uncredited) | Jordan (uncredited) |
| MMary LiswoodAngie Fitch - Raymond's Wife (uncredited) | Angie Fitch - Raymond's Wife (uncredited) |
| HHenry MametAnson (uncredited) | Anson (uncredited) |
| TTiger Joe MarshBosun on Nile Queen (uncredited) | Bosun on Nile Queen (uncredited) |
| RRuth Moore MathewsMrs. Dubin (uncredited) | Mrs. Dubin (uncredited) |
 Emile MeyerCapt. Beauclyde - Master of Nile Queen (uncredited) | Capt. Beauclyde - Master of Nile Queen (uncredited) |
 Alex MinotisJohn Mefaris - Restaurant Owner (uncredited) | John Mefaris - Restaurant Owner (uncredited) |
| RRex MoadWynant (uncredited) | Wynant (uncredited) |
| RRay MüllerDubin (uncredited) | Dubin (uncredited) |
 Lenka PetersonJeanette - Charlie's Girlfriend (uncredited) | Jeanette - Charlie's Girlfriend (uncredited) |
| WWaldo PitkinBen (uncredited) | Ben (uncredited) |
 Tommy RettigTommy Reed (uncredited) | Tommy Reed (uncredited) |
