Jane, a young soldier, is exposed to a biochemical weapon that endows her with self-healing powers. She uses her abilities to fight crime while eluding the military.
| Actor | Role |
|---|---|
 Emmanuelle VaugierJane Browning / Painkiller Jane | Jane Browning / Painkiller Jane |
 Eric DaneNick | Nick |
 Richard RoundtreeColonel Watts | Colonel Watts |
 Venus TerzoCarla Browning | Carla Browning |
 Walker HowardBlue | Blue |
 Callum Keith RennieMitchell | Mitchell |
 Tate DonovanDr. Graham Knight / Lucas Insley | Dr. Graham Knight / Lucas Insley |
 Paula BrancatiYoung Jane | Young Jane |
| EElicia MackenzieYoung Carla | Young Carla |
 Martin CumminsSergeant Flynn | Sergeant Flynn |
 Richard HarmonSqueak | Squeak |