 Fredric MarchWilliam Spence | William Spence |
 Martha ScottHope Morris Spence | Hope Morris Spence |
 Beulah BondiLydia Sandow | Lydia Sandow |
 Gene LockhartPreston Thurston | Preston Thurston |
 Elisabeth FraserEileen Spence at Age 17 | Eileen Spence at Age 17 |
 Harry DavenportElias Samson | Elias Samson |
 Laura Hope CrewsMrs. Preston Thurston | Mrs. Preston Thurston |
 Grant MitchellClayton Potter | Clayton Potter |
 Moroni OlsenDr. John Romer | Dr. John Romer |
 Frankie ThomasHartzell Spence | Hartzell Spence |
 Jerome CowanDr. Horrigan | Dr. Horrigan |
 Ernest CossartJohn E. Morris | John E. Morris |
 Nana BryantMrs. Morris | Mrs. Morris |
| CCarlotta JelmEileen Spence | Eileen Spence |
| PPeter CaldwellHartzell Spence | Hartzell Spence |
| CCasey JohnsonFrazer Spence | Frazer Spence |
 Dorothy AdamsWoman Behind Hope at Baptism (uncredited) | Woman Behind Hope at Baptism (uncredited) |
| JJoan AndersonChild (uncredited) | Child (uncredited) |
 Roscoe AtesGeorge Reynolds (uncredited) | George Reynolds (uncredited) |
 Leah BairdUndetermined Secondary Role (uncredited) | Undetermined Secondary Role (uncredited) |
 Clara BlandickSister Watkins (uncredited) | Sister Watkins (uncredited) |
 Hobart BosworthRichard Hardy Case (uncredited) | Richard Hardy Case (uncredited) |
| JJed BreslauChild (uncredited) | Child (uncredited) |
 Harlan BriggsMac MacFarland (uncredited) | Mac MacFarland (uncredited) |
 Virginia BrissacMrs. Jellison (uncredited) | Mrs. Jellison (uncredited) |
| MMary BrodelSecond Bride (uncredited) | Second Bride (uncredited) |
 Sonny BuppBoy (uncredited) | Boy (uncredited) |
 Chester ConklinMan Crying During Baptism (uncredited) | Man Crying During Baptism (uncredited) |
| TTed CraneChild (uncredited) | Child (uncredited) |
 Charles DrakeSecond Bridegroom (uncredited) | Second Bridegroom (uncredited) |
