 Antonio BanderasEl Mariachi | El Mariachi |
 Johnny DeppCIA Agent Jeffrey Sands | CIA Agent Jeffrey Sands |
 Cheech MarinBelini | Belini |
 Salma Hayek PinaultCarolina | Carolina |
 Mickey RourkeBilly Chambers | Billy Chambers |
 Willem DafoeArmando Barillo | Armando Barillo |
 Eva MendesCIA Agent Ajedrez | CIA Agent Ajedrez |
 Danny TrejoCucuy | Cucuy |
 Rubén BladesJorge, Retired FBI Agent | Jorge, Retired FBI Agent |
 Enrique IglesiasLorenzo | Lorenzo |
 Marco LeonardiFideo | Fideo |
 Troy RobinsonRomero | Romero |
| GGerardo VigilGeneral Marquez | General Marquez |
 Pedro Armendáriz Jr.President of Mexico | President of Mexico |
 Julio Oscar MechosoNicholas, Presidential Advisor | Nicholas, Presidential Advisor |
 Tito LarrivaCab Driver | Cab Driver |
| MMiguel CouturierDr. Guevera | Dr. Guevera |
| TTony ValdesChicle Boy | Chicle Boy |
| JJosé Luis AvendañoAlvaro | Alvaro |
| RRodolfo De AlexandreOmar | Omar |
| NNatália TorresEl Mariachi's Daughter | El Mariachi's Daughter |
| SSteve ConstancioRight Hand | Right Hand |
| EErmahn OspinaQui-Que | Qui-Que |
| LLuz María RojasPistolera | Pistolera |
| MMario SimonCook | Cook |
| BBernard HackerBlascoe | Blascoe |
| CCecilia TijerinaWaitress | Waitress |
| CCarola VázquezHospital Administrator | Hospital Administrator |
| RRené GaticaChief Federale | Chief Federale |
| SSilvia SantoyoBachelorette | Bachelorette |
